The second special topics issue of Operating Systems Reviews will be related to Operating and Runtime System Support for High-End Computing Systems. Patrick Bridges (bridges@cs.unm.edu), Barney Maccabe (maccabe@cs.unm.edu), and Orran Krieger (okrieg@us.ibm.com) will be guest editors. For this issue, we seek submissions on all aspects related to operating systems for high-performance scientific computing systems. This includes operating and runtime system support for large-scale commodity clusters, distributed memory multiprocessors, and shared memory multiprocessors. Short overviews of mature projects and experience reports are welcome, as well as papers outlining ideas for new directions, and everything in between. Topics of interest include: - Custom kernel support for large-scale machines and applications - Network and messaging issues in supercomputing systems - Programming environments and models - Scalable file systems - Job launch and system management facilities - Scalable debugging and monitoring systems - OS/application interaction studies - Fault tolerance and checkpointing - OS experiences in deployed HEC systems Papers will be reviewed by the guest editors with the assistance of outside referees. The primary criteria for acceptance consist of broader interest to the systems community, potential consequences for systems builders, and clarity of exposition. Position papers are welcome, as are short (1 to 2-page) notes on commonly encountered problems or ongoing work that relates to HEC operating systems. This special issue does not have a predefined format or a target number of accepted papers, but there is a soft cap of roughly 84 pages of text devoted to papers. Papers should be double column including figures and tables in standard ACM format and submitted as printable PDF. If you are interested in submitting to this issue of OSR, please send email to bridges@cs.unm.edu with a brief description of your submission by February 1, 2006. The final submission will be due February 15, 2006.